The 29-year-old Australian dumped Federer, who last won the tournament in 2008, in four sets, 3-6, 7-5, 7-6, 7-6, with the last two sets going to tiebreak. The feet weren't moving.
Sousa, who got past 12th-seeded Pablo Carreno Busta and No. 17 Luca Pouille to become the first Portuguese man to reach a Grand Slam last 16, was "not happy" at Djokovic's first lengthy absence from the court, although he acknowledged there was no rule limiting time of a comfort break.
Federer started the match well, breaking his opponent to love in his first service game to take a 2-0 lead and not yielding any break chances as he sealed the opener at the third attempt. Roger had it on a string, he was manipulating me around the court.
His serve, in particular, was way off during the first two sets.
Things grew tougher in the second as a sluggish Djokovic laboured before again clinching the set with a break. "Sometimes, you just have to survive". I have had three surgeries and every time I had extreme doubts over whether I would get back. "I have prayed for that".
I Would Never Want Egoistic Cristiano Ronaldo in My Team - Zlatko Dalic
Barcelona manager Ernesto Valverde says his side are up against a "powerful group " after drawing Tottenham , Inter Milan and PSV Eindhoven in Thursday's Champions League draw in Monaco . "There will be a lot of passion around our matches in this group with Napoli, Liverpool and Red Star".
Djokovic did his part improving his ideal NY record in fourth round contests to 11-0 leaving it to Federer, who will take on Australian John Millman in the late contest on Arthur Ashe Stadium court to give the fans what would be a hotly anticipated match-up.
Second seed Federer, who had not dropped a set in his first three matches, was uncharacteristically sloppy, committing 77 unforced errors and 10 double faults while landing just 49 percent of his first serves.
Djokovic said it used to be Andy Roddick but since the American's retirement from the sport, Aussie Nick Kyrgios was probably the next best.
7-6 (7/3) victory in his first Grand Slam fourth round match scuppered a blockbuster quarter-final between Federer and two-time victor Novak Djokovic.
Congress bids farewell to Sen. John McCain
The former aviator who was a prisoner of war for more than five years will be buried Sunday at his college alma mater, the U.S. Senator John McCain paid a last visit to the Capitol on Friday before services Saturday at the Washington National Cathedral.
"He pushed me around, " Kohlschreiber said after Nishikori reached the final eight for a second straight Grand Slam tournament.
An elbow injury forced the 31-year-old out of the 2017 tournament though Djokovic reached the final 12 months previously, beaten by Stan Wawrinka.
"I don't have any pressure, " said Nishikori, who was so crushed about missing the US Open a year ago that he couldn't even watch the tournament.
Twarit Vishwa: Four killed in bus crash in New Mexico
Preliminary information indicates a semi-truck traveling the opposite way had a blow-out and crashed head-on into the bus. The driver lost control of the vehicle , which crossed the median and struck the westbound bus, Wilson told reporters.