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Hospitals in Gallup said they have been told to be ready to receive eight patients. UNM officials didn't release any details about the patients' conditions. He did not have any information on the people who were killed, including their ages, genders or where they were from.

"It was awful, there was people trying to climb out of the windows of the bus. bystanders trying to help people getting ladders out of their truck to get to windows of Greyhound bus to assist", a witness told KRQE.

Preliminary information indicates a semi-truck traveling the opposite way had a blow-out and crashed head-on into the bus.

At least four people are dead and several others are hurt following a crash involving a Greyhound bus and tractor trailer, according to a local hospital. One survivor, Rachel Cunningham, who said she was asleep on the Greyhound when the crash happened, woke up to a gaping hole in the bus' passenger side.

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Chris Jones said in a phone interview that he was headed west Thursday on Interstate 40 near the Arizona state line when he saw a semi-truck on its side. The driver lost control of the vehicle, which crossed the median and struck the westbound bus, Wilson told reporters.

Gaines said the crash was the "largest mass casualty event" he has seen at the center.

A spokeswoman for Greyhound said the company is cooperating with local authorities and will do its own investigation.

Emergency personnel inspect a bus near Thoreau after it was destroyed by the impact of an oncoming semitrailer Thursday. "Many bus passengers were transported with serious injuries".

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The westbound lanes of the interstate closed as a result of the crash. "The first few officers that arrived on scene really had their hands full".

Aerial footage by CNN affiliate KRQE showed the bus damaged on the front edge, but upright, in the grass median. Debris from the semi also littered the area.

It was not immediately known how many were injured or what the conditions of the injured were.

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