One village was extremely affected by running lava causing deaths and injuries.
National Disaster Coordinator Sergio Cabanas says an undetermined number of people also are missing following Sunday's eruption of the Volcan del Fuego, which is 44 kilometers (27 miles) from Guatemala City.
This is the second time the volcano has erupted this year.
The volcano is located about 25 miles south-west of the capital Guatemala City.
The volcano spewed black smoke and ash into the sky, prompting the evacuation of some 100 people and forcing the capital's La Aurora global airport to shut down its only runway.
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Firefighters said late Sunday that they had seen some people who were trapped in the area, but roads leading there were cut by pyroclastic flows and they had been unable to reach them. In darkness and rain, the rescue effort was ordered suspended until early morning, municipal firefighters spokesman Cecilio Chacaj said.
"Not everyone escaped, I think they were buried", Consuelo Hernandez said.
The eruption affects an area home to 1.7million people.
"Currently the volcano continues to erupt and there exists a high potential for (pyroclastic) avalanches of debris", the disaster agency said late Sunday via Twitter, quoting Sanchez, the director of the seismology and volcanology institute.
President Jimmy Morales informed that a national emergency response team has been activated. Streets and houses were covered in the colonial town of Antigua, a popular tourist destination.
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Another 20 people have been injured, and more than 2,000 evacuated near the volcano and several cities, including Antigua.
The conical Volcan de Fuego is 12,346 feet above sea level at its peak.
Residents have been urged to wear masks due to the falling ash.
Mario Cruz, a spokesman for the volunteer firefighter corps, said 3,100 people had evacuated the area so far.
The eruption forced the Guatemala City's La Aurora global airport to shut down its only runway due to the presence of volcanic ash and to guarantee passenger and aircraft safety, Guatemala's civil aviation authority said in a Tweet.
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