A second border patrol agent was able to pull over the second vehicle but the third refused to stop. Boyd said the Suburban was being chased by a Dimmit County deputy.
CNN has reached out to local authorities and is waiting to learn details of the crash. The driver was not seriously injured and taken into Homeland Security custody, Dimmit County Sheriff Marion Boyd told reporters.
According to WOAI 5 people were transported to San Antonio Military Medical Center. Boyd tells San Antonio television station WOAI a driver and one passenger are believed to be USA citizens. 12 immigrants were ejected and four died on scene.
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One of the drivers attempted to flee the scene and was chased by agents, US Border Patrol said in a statement.
An SUV carrying 14 people rolled over and ejected 12 people who are believed to be illegal immigrants, according to a report from News4SanAntonio.
Some of the wounded were thrown from a auto packed with 14 people that was travelling at 100mph (160km/h), County Sheriff Marion Boyd told KFDM News TV.
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Out of 14 people in the auto, four were killed on the spot while a fifth person died at the hospital in San Antonio, the Dimmit County Sheriff said.
It's not an uncommon sight for Boyd, who said Sunday it's very rare that a day goes by that his deputies do not get involved in a chase due to some form of smuggling from the border.
The vehicle traveling more than 100 miles per hour when it crashed, according to local authorities. "This is a flawless example of why our borders need to be secure", he added.
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Boy believes the driver was scouting the area to try and pick up immigrants.
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