He also accused Washington of engaging in conflict with Iran and shifting its cost to others.
According to the publication, on the eve of labor Day, he met with thousands of workers and urged Iranians to support the national economy by buying products produced in the home country.
"US's plan is to provoke some ignorant govts. with little knowledge, in our own region, to confront the Islamic Republic", he says.
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"The U.S. incites the Saudis in order to create conflict in our region".
"Americans are the ones who should leave.The Middle East, the west of Asia and the Persian Gulf is our home", Khamenei said.Iranian state TV quoted Iran´s Foreign Ministry spokesman Bahram Qasemi as saying Tehran would keep on backing its friends in the region despite U.S. pressure to curb its influence.
Iran's supreme leader then warned the regional powers from giving in to the United States provocations, adding that, if they face Iran, they will "suffer a decisive defeat".
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Khamenei comments are coming days after Hassan Rouhani, the president of Iran kicked against moves by French President Emmanuel Macron, alongside his United States counterpart Donald Trump, regarding a potential "new nuclear deal". The U.S. has denied being behind the attack, which may have killed a number of Iranians and their allies, while Israel has remained silent. The U.K. -based, pro-oppositon Syrian Observatory for Human Rights said Israel appeared to be behind the attack, which may have killed a number of Iranians, as well as Syrians.
Iranian officials on Monday reiterated that Tehran had no intention of suspending its defensive missile capability. Appearing to address those remarks, Khamenei said Iran had no intention of limiting its influence in the Middle East. He then warned that if the United States or any of its allies decide to attack the Islamic Republic or its bases, their actions will be met with a "much stronger response". "The Middle East, the west of Asia and the Persian Gulf is our home".
The attack coincided both with Israeli threats of further strikes and flare-ups between Iran-backed, pro-Syrian government fighters and USA -backed militias in eastern Syria. "They know that if they attack, they will receive stronger counterattacks", he added.
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