Salah will revisit the Stadio Olimpico on May 2 for the second leg of the semifinal tie.
The Reds famously beat Roma in the European Cup final in 1984 and Salah sees no reason why Jurgen Klopp's men can not lift the trophy again in Kiev next month. The winners will face the victor of the other semi-final between Liverpool and AS Roma in the final in Kiev on 26 May.
The Europa League final will be in Lyon, France on Wednesday, 16 May, with the victor guaranteed a place in next season's Champions League.
The last time the two sides faced each other in a competitive fixture was in the Champions League group stages in 2002.
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Real, who have won the competition 12 times, reached the semi-finals by fighting off a remarkable Juventus comeback before Ronaldo scored a late penalty to give them a 4-3 win on aggregate.
"If anybody thinks this is the easiest draw then I can not help this person", said Liverpool boss Jurgen Klopp.
"I didn't see the first leg, but how boring Barcelona are", the former Red told Italian daily La Repubblica when asked about Roma knocking out Barcelona.
Marseille overcame a first-leg deficit to beat German side Leipzig 5-3 over two legs in their quarter-final, while 1994 finalists Salzburg produced the shock result of the night by defeating Italian side Lazio 4-1 at home to win 6-5 on aggregate.
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"It is just the draw and I know it is very exciting, but it is good because the most important news is we are still in the competition".
"If anybody thinks this is the easiest draw then I can not help this person", said Liverpool boss Jurgen Klopp."They obviously didn't see both games against Barcelona".
The second legs will be played in Madrid on May 1 and in Rome the following day.
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