The writer-director of "Lady Bird", Greta Gerwig, won best director and best screenplay as the society voted in NY on Saturday.
Saoirse had been touted as a potential victor in the build-up to the ceremony and so it proved on Sunday night as she came away with the award for Best Performance by an Actress in a Motion Picture - Musical or Comedy for her role as a high-school student in the coming-of-age movie Ladybird.
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Gerwig was shut out of the best director category. Many in the industry believe that Gerwig missed a well-deserved nomination in the director category at the Globes, which was won by Guillermo del Toro for "The Shape of Water".
She added: "I just want to say how inspiring it's been to be in this room tonight".
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"It's my mum's birthday tomorrow; she likes this kind of thing", said Martin McDonagh, accepting his award.
Actor-director James Franco was the Best Actor - Musical or Comedy victor for his film, The Disaster Artist.
"If the movie wins, and even me getting [this award], that's her's", Ronan insisted. The actress is up for Best Performance by an Actress in a Motion Picture - Musical or Comedy.
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After seeing Edmund's distress, Dimitrov immediately leaped over the net and sprinted to his aid, helping the Briton to his chair. Dimitrov will now play mercurial Australian Nick Kyrgios in a blockbuster semi-final.