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The study included 31 men, ages 18-35. The samples showed that applying ibuprofen triggered a dose-dependent drop in the production of testosterone within 48 hours. Some took 1,200 milligrams of ibuprofen daily, which is the maximum limit as directed, over a six-week period.

Ibuprofen belongs to a group of drugs called non-steroidal anti-inflammatories, or NSAIDs, that work by blocking the production of hormone-like signaling molecules called prostaglandins, which theoretically reduces pain and inflammation.

The researchers also observed other hormonal disruptions at 14 and 44 days of ibuprofen consumption, suggesting wide-ranging consequences of hypogonadism. "Taken together, these in vivo data suggest that ibuprofen induced a state of compensated hypogonadism during the trial..." the study states.

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Taking the common painkiller ibuprofen has been linked in a small study with a condition affecting male fertility problems.

"We normally see this condition in elderly men, so it raises an alarm", Jégou said.

The researchers found that, compared with the placebo group, the men who took ibuprofen experienced a 23 percent increase in levels of luteinizing hormone (LH) - a hormone that's secreted by the pituitary gland and stimulates the production of testosterone - after two weeks.

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Ibuprofen was of particular interest, the researchers say, because of its increased use in the general population in professional athletes around the world. So, for the time being, I would urge men who need to take ibuprofen to continue to do so.

"It is sure that these effects are reversible", study author Bernard Jégou, of the French National Institute of Health and Medical Research, told CNN.

They found that all three drugs are "anti-androgenic", meaning that they can disrupt male hormones, as David M. Kristensen, study co-author and a senior scientist in the Department of Neurology at Copenhagen University Hospital told CNN. Long term, it can lead to a more serious condition called overt primary hypogonadism, which is characterized by low testosterone and libido, depressed mood and reduced muscle mass and strength.

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The study only focused on a small group of participants, so more research will be needed before the affects of ibruprofen are fully established. A similar study in 2016 also found that the common painkiller could exacerbate heart failure.


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